Description
Recombinant full-length human USP15 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. The USP15 gene accession number is NM_001252078.
USP15 (ubiquitin carboxyl-terminal hydrolase 15) is a member of the ubiquitin specific protease (USP) family of cysteine protease deubiquitination enzymes and regulates TGFB receptor signaling, NF-kappa-B and RNF41/NRDP1-PRKN pathways. The enzyme interacts with OP9 signalosome and is a key regulator of TGFB receptor signaling through deubiquitination of receptor-activated SMAD transcription factors (1). USP15 also plays a role in the regulation and stabilization of Human Papillomavirus (HPV) type 16 E6 protein, suggesting that E6 may be a target for USP15 DUB activity (2)